L. Basco, O. Ramiliarisoa, P. Ringwald
Apr 1, 1993
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0
Influential Citations
5
Citations
Quality indicators
Journal
Antimicrobial Agents and Chemotherapy
Abstract
The in vitro activity of cycloguanil was assessed against 86 African isolates of Plasmodium falciparum by a semi-micro assay system. A bimodal distribution of susceptibility patterns was observed, with 44% of the isolates being cycloguanil susceptible. Cycloguanil alone retains a high activity against the intraerythrocytic forms of some isolates and, together with its activity against the hepatic stages, may be useful for chemoprophylaxis when combined with chloroquine.