Kumar B.R. Chaitanya, Babu K. Sudhakar, Murthy D V Krishna
Jan 25, 2022
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Journal
Research Journal of Chemistry and Environment
Abstract
The metal complexes of pyridine derivative ligand 2- ((E)-2-(1-(4-methylpyridin-2-yl)ethylidene)hydrazinyl) -4-methyl-6-phenylpyridine-3-carbonitrile (MPHPC) derived from 2-hydrazinyl-4-methyl-6-phenylpyridine- 3-carbonitrile and 1-(4-methylpyridin-2-yl)ethanone with metals [Co, Ni and Cu] have been synthesized and characterized with different spectral investigations viz.UV-Vis, FT-IR, 1H-NMR and ESR. The ligand and metal complexes were screened for in vitro cytotoxicity studies against two carcinoma cell lines A549 (Lung carcinoma cells) and HepG2 (Hepatocellular carcinoma cell). The results were found to possess cytotoxic effect. The ligand and metal complexes were screened for in vitro antibacterial activities against for pathogenic bacterial strains such as gram –ve bacteria like Pseudomonas desmolyticum, Escherichia coli and Klebsiella aerogenes as well as gram +ve bacteria like Staphylococcus aureus. The antibacterial studies were determined by agar well diffusion method using DMSO as negative control and Ciprofloxacin as positive control. Cobalt and nickel complexes show a moderate sensitivity whereas copper complex has significant activity at higher doses.