Kathleen Too, Daniel M. Brown, D. Loakes
Nov 26, 2007
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
A library of N 6 -hydroxy-, methoxy-, or amino-adenosine analogs was prepared and screened for anti-malarial properties. We found three compounds that possess anti-plasmodial activity in the low micromolar range against the multi-drug resistant VS1 strain, namely N 6 -hydroxy-9H-purin-6-amine (IC 50 5.57 μ M), 2-amino-N 6 -amino-adenosine (IC 50 12.2 μ M), and 2-amino-N 6 -amino-N 6 -methyladenosine (IC 50 0.29 μ M). More importantly, the compounds were non-toxic, with 2-amino-N 6 -amino-N 6 -methyladenosine showing a selectivity index of 5008.