Rupanjali Sharma, A. Goswami, M. Rudrapal
Dec 1, 2016
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Current Science
Abstract
A simple Schiff base, N-(pyridine-4-yl-methylene) quinuclidine-3-amine was synthesized from 3-amino-quinuclidine and 4-pyridine carboxaldehyde. The physico-chemical properties of the synthesized com-pound were studied. Molecular docking study was carried out and the quinuclidine derivative was evaluated for its in vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum strain. Although higher dose of synthesized compound was required for antimalarial activity (EC 50 = 13.125 μg/ml) in comparison to chloroquine (EC 50 5.144 μg/ml), the correlation coefficient confirmed good fit of the data. Furthermore, the result of the molecular docking provided insights into the ligand-protein interactions responsible for the inhibitory potency.