B. A. Stander, Fourie Joubert, A. Joubert
Feb 1, 2014
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Journal
South African Journal of Science and Technology
Abstract
In vitro evaluation of a novel Estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity. In the present study we describe the in vitro biological activity of 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol), a novel antimitotic compound with anticarbonic anhydrase activity. This study indicates that ESE-15-ol is a promising antimitotic anticancer drug that warrants further investigation.