Fany L. Guerra, J. Rager, S. Bhoopathy
Mar 26, 2012
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Quality indicators
Journal
Investigative Ophthalmology & Visual Science
Abstract
Purpose Latanoprost is an isopropyl ester prostaglandin F 2 ∂ analogue prodrug indicated for the treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Latanoprost is hydrolyzed in the eye to the biologically active metabolite, latanoprost acid. The objective of this study was to assess the extent of latanoprost hydrolysis in various ocular tissues dissected from fresh human eye globes. Insight into the enzymatic activity of these tissues is useful for the interpretation of human data and the design and testing of new drugs for ophthalmology.