J. Willaert, G. Lemiére, R. Dommisse
Sep 1, 2010
Citations
0
Influential Citations
2
Citations
Journal
Bulletin des Sociétés Chimiques Belges
Abstract
3-Cyanocyclohexanone is a suitable substrate for preparative HLAD reduction, delivering enantiomerically pure (1S, 3S)-trans and (1R, 3S)-cis-alcohols. Details are given on the kinetics of the reduction and the absolute configuration of the products. In contrast to recently developed reaction models an important amount of (1R,3S)-cis-alcohol is formed. Some side reactions of the substrate with the TRIS-buffered medium are described.