O. Al-Gohary
1991
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
Abstract The in vitro uptake of mebeverine hydrochloride onto magnesium trisilicate powder has been investigated. Adsorption data were obtained at temperatures 25, 37 and 50°C, with respect to changes in pH values from 0.8 to 7.73 and the presence of electrolytes. The calculated data were in accordance with Langmuir isotherms. The Langmuir constants and the thermodynamic functions were determined for the reaction. The results showed that adsorption was endothermic. Only partial elution of adsorbed drug occurred in different elution media. Dissolution of the tablets or capsules was adversely affected. The antacid efficacy of magnesium trisilicate was evaluated alone and in the presence of the pure drug or its dosage forms. It was shown that the acid reactivity of the antacid was affected and suppressed to a great extent.