M. Isono, K. Kawashima, N. Yamada
Jul 1, 1982
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0
Influential Citations
1
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Quality indicators
Journal
The Japanese journal of antibiotics
Abstract
Cefmetazole was investigated on stability to beta-lactamases produced by Bacteroides fragilis and on therapeutic effects in mice infected with B. fragilis. 1. Cefmetazole, like other cephamycins, was found extremely stable to beta-lactamases obtained from B. fragilis. 2. Cefmetazole showed good antimicrobial activities to 50 strains of B. fragilis and extremely high stability to their beta-lactamases. 3. Cefmetazole showed an excellent protecting effect to infections due to beta-lactamase producing B. fragilis. 4. Cefmetazole exhibited an excellent chemotherapeutic effect against polymicrobial infections in mice due to E. coli (beta-lactamase -)and B. fragilis (beta-lactamase +).