F. Benencia, M. Courreges
Nov 1, 2000
Citations
2
Influential Citations
151
Citations
Quality indicators
Journal
Phytotherapy Research
Abstract
Eugenol (4‐allyl‐1‐hydroxy‐2‐methoxybenzene) was tested for antiviral activity against HSV‐1 and HSV‐2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti‐HSV effects of eugenol were 25.6 µg/mL and 16.2 µg/mL for HSV‐1 and HSV‐2 respectively, 250 µg/mL being the maximum dose at which cytotoxicity was tested. Eugenol was virucidal and showed no cytotoxicity at the concentrations tested. Eugenol–acyclovir combinations synergistically inhibited herpesvirus replication in vitro. Topical application of eugenol delayed the development of herpesvirus induced keratitis in the mouse model. Copyright © 2000 John Wiley & Sons, Ltd.