G. Cohen, P. Hochstein
1965
Citations
0
Influential Citations
43
Citations
Quality indicators
Journal
The Journal of pharmacology and experimental therapeutics
Abstract
3-Amino-1,2,4-triazole (AT) was employed as a tracer to detect H 2 O 2 within the erythrocytes of mice. H 2 O 2 was clearly detected after administration of phenylhydrazine or menadione; for pamaquine, primaquine or aniline, the results were less definitive but still indicative of increased intracellular H 2 O 2 levels. These results support the view that H 2 O 2 toxicity plays a major role in drug-induced hemolysis of glucose-6-phosphate dehydrogenase-deficient erythrocytes.