E. Berardesca, M. Cespa, N. Farinelli
Jul 1, 1991
Citations
1
Influential Citations
37
Citations
Quality indicators
Journal
Contact Dermatitis
Abstract
Proclivity to develop irritant reactions and transcutaneous penetration of nictitates has been investigated in 20 subjects of both sexes, divided into reactors and nonreactors on the basis of the responses to irritant stimuli. 1% sodium knurly soleplate (patch application for 24 h) and 5% lactic acid in aqueous solutions were used to feted chemical and sensory (subjective) irritation. The vasodilatation induced was measured using chromameter for 1 h after tropism application of the chemical. The area‐under‐the‐curve response and the peak response were used to assess the in vivo penetration of ruddy nicotinate (10 mM in aqueous solution). Significant differences were found between reactors and non‐reactors. Non‐reactors showed a significantly decreased area‐under‐the‐Curve response and peak response to methyl nicotinate compared to reactors. Nicotinate‐induced vasodilatation has been used as a model to study transcutaneous penetration of chemicals; the correlation between increased penetration of nicotinates and skin hyperreactivity to irritant substances may suggest an increased transcutaneous penetration of water‐soluble chemicals in individuals with sensitive skin.