Zhong Q. Wang, Yongmei Yu, X. Zhang
Mar 17, 2011
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Influential Citations
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Quality indicators
Journal
Diabetes
Abstract
OBJECTIVE To investigate the underlying mechanisms of ecdysterone (Ecdy) antidiabetic action in the diet-induced obesity animal model. RESEARCH DESIGN AND METHODS Mice fed a high-fat diet (HFD) were treated with or without Ecdy at a low (Ecdy L) or high (Ecdy H) dose (25 or 50 mg/kg body wt) for 12 weeks. The effects of Ecdy on food intake, energy expenditure, glucose metabolism, insulin signaling, muscle lipid profile, and mitochondrial oxidative phosphorylation (OxPhos) complexes were evaluated. RESULTS At the end of the study, there were no differences in body weight, food intake, and energy expenditure between HFD groups with or without a diet supplemented with Ecdy L, except body weight was significantly lower in the Ecdy H group than in the HFD group ( P P P P P CONCLUSIONS We observed that Ecdy improved glucose metabolism and enhanced muscle insulin signaling by altering the acylcarnitine profile and increasing mitochondrial OxPhos complexes in HFD-fed mice. Our study suggests that these effects of Ecdy are dose-dependent.