M. Jebari, Karine Pasturaud, Baptiste Picard
Nov 29, 2016
Citations
0
Influential Citations
4
Citations
Journal
Organic & biomolecular chemistry
Abstract
Poorly nucleophilic aromatic amines (nitroanilines, chloroanilines, etc.) react readily and selectively with trans-4-methoxy-3-buten-2-one, a convenient, effective and inexpensive surrogate for 3-butyn-2-one, to afford (Z)-enaminones. The efficiency of the reaction mostly lies in the use of water as a solvent, which enhances the reaction rate by a 45 to 200-fold factor with regard to other media.