Y. Wan, R. H. Williams, K. Folkers
Mar 3, 1975
Citations
0
Influential Citations
69
Citations
Journal
Biochemical and biophysical research communications
Abstract
Summary 2,3-Dimethoxy-5-methyl-6-n-pentyl-, -6-n-decyl-, and -6-n-pentadecyl-1,4-benzoquinones were synthesized as analogs of coenzyme Q 1 , Q 2 , and Q 3 , respectively. The 6-substituents of the three pairs of quinones have 5, 10, and 15 carbon atoms. These analogs are more stable than the isoprenoid Q's, and have advantages in biochemical experiments. These low molecular weight analogs have inadequate lipoidal characteristics to simulate the higher molecular weight CoQ's including CoQ 10 . However, if lipoidal characteristics are not essential, the pentyl and decyl analogs are highly effective as evidenced by their functioning like CoQ 1 and Q 2 as hydrogen acceptors with ETPH particles for oxidative phosphorylation at site I, and after reduction as hydrogen donors for complex III.