E. Constable, C. Housecroft, B. Kariuki
Jun 1, 2006
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Influential Citations
3
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Journal
Supramolecular Chemistry
Abstract
The conversion of 2,2′-bipyridine (bpy) to 4,4′-disubstituted derivatives is commonly achieved by a route involving preparation of the N,N′-dioxide and subsequent nitration with HNO3/H2SO4. The yields in the latter reaction are of the order of 50% and we now show that a competing ring oxidation process leads to the formation of 4-nitropicolinic acid. The solid state structure of the monohydrate of 4-nitropicolinic acid is reported, which exhibits a series of interesting packing motifs arising from hydrogen bonding networks.