R. Shelton
1981
Citations
0
Influential Citations
28
Citations
Journal
Journal für die reine und angewandte Mathematik (Crelles Journal)
Abstract
The present invention relates to new triazole derivatives of the formula (I) wherein R1 represents hydrogen, lower alkyl, optionally esterified or etherified hydroxymethyl, formyl, optionally functionally modified carboxy, or optionally mono- or disubstituted aminomethyl, R2 represents lower alkyl, and R3 represents hydrogen or lower alkyl, whereby R2 and R3 as lower alkyl can be bound directly, or in beta - or gamma -position also by way of oxygen, sulphur or the imino radical or a lower alkylimino radical, and the rings A and B independently of each other can be unsubstituted or substituted, and to their addition salts with inorganic and organic acids, in particular the pharmaceutically acceptable acid addition salts. These new compounds possess valuable pharmacological properties. In particular they have an anti-convulsive activity and are useful for the treatment of epilepsy and of conditions of tension and of agitation. Specific embodiments are 1-[2-(o-chlorobenzoyl)-4-chlorophenyl]-5-(morpholinomethyl)-1H-1,2,4-t riazole-3-carboxamide,1-[2-(o-chlorobenzoyl)-4-chlorophenyl]-5-[(dimet hylamino)-methyl]-1H-1,2,4-tariazole-3-carboxamide, N-methyl-1-[2-(o-chlorobenzoyl)-4-chlorophenyl]-5-(morpholinomethyl)-1 H-1,2,4-triazole-3-carboxamide, N-ethyl-1-[2-(o-chlorobenzoyl)-4-chlorophenyl]-5-(morpholinomethyl)-1H -1,2,4-triazole-3-carboxamide, N-ethyl-1-[2-(o-chlorobenzoyl)-4-chlorophenyl]-5-[(dimethylamino)-meth yl]-1H-1,2,4-triazole-3-carboxamide, N-propyl-1-[2-(o-chlorobenzoyl)-4-chlorophenyl]-5-[(dimethylamino)-met hyl]-1H-1,2,4-triazole-3-carboxamide, N,N-dimethyl-1-[2-(o-chlorobenzoyl)-4-chlorophenyl]-5-[(dimethylamino) -methyl]-1H-1,2,4-triazole-3-carboxamide, and N,N-dimethyl-1-[2-(o-fluorobenzoyl)-4-chlorophenyl]-5-[(dimethylamino) -methyl]-1H-1,2,4-triazole-3-carboxamide.