Makoto Yoritate, Allyn T. Londregan, Y. Lian
Nov 18, 2019
Citations
1
Influential Citations
8
Citations
Journal
The Journal of organic chemistry
Abstract
Molecules containing trifluoromethoxyaryl groups are of interest in pharmaceutical, agrochemical, and materials science re-search, due to their unique physical and electronic properties. Many of the known methods to synthesize trifluoromethoxy-aryl ethers require harsh reagents, highly-controlled reaction conditions, and rarely occur when heteroaromatic units are pre-sent. The two-step O-trifluoromethylation of phenols via aryl-xanthates is one such method that suffers from these draw-backs. Herein, we report a facile synthesis of aryl trifluoromethyl ethers from phenols by the facile conversion of the phenol to the corresponding aryl and heteroaryl xanthates with newly synthesized imidazolium methylthiocarbonothioyl salt and conversion of these xanthates to the trifluoromethyl ethers under mild reaction conditions.