Jun-Hui Zhou, Yang Li, Lei Zhang
Jul 10, 2012
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Journal
Natural Product Research
Abstract
Ranaconitine is an important diterpenoid alkaloid from Aconitum sinomontanum Nakai. The absolute configuration of natural ranaconitine was determined through an X-ray structure analysis of hydrated ranaconitine hydrobromide. The crystal presents a monoclinic system, space group P21 with Z = 2, unit cell dimensions: a = 10.6604(12) Å, b = 12.3674(14) Å, c = 12.2938(13) Å and β = 91.056(2)°. The chirality of the asymmetric carbon atoms was as follows: C10(S), C13(S), C14(S), C15(S), C16(S), C17(R), C23(S), C25(R), C26(S), C27(S), C28(S) and C30(S). Moreover, a complex network of hydrogen bonds occurred between neighbouring molecules.