Ehab Khalil, N. Subasinghe, Rodney L. Johnson
May 13, 1996
Citations
0
Influential Citations
46
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An improved method for the N - tert -butoxycarbonyl protection of the amino functionality of α-alkylated prolines and other sterically hindered α,α-disubstituted amino acids has been developed in which the lipophilic base tetramethylammonium hydroxide is used to solubilize the otherwise insoluble zwitterionic amino acid in acetonitrile, thereby obviating the need for an aqueous medium.