Vijayakumar N. Sonar, Sean Parkin, P. Crooks
Feb 15, 2006
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Journal
Acta Crystallographica Section E-structure Reports Online
Abstract
In view of the biological activity associated with 1-azabicyclo[2.2.2]octan-3-ones, we have undertaken the synthesis and structural analysis of a series of 2-(substituted benzylidene/heteroaryl-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3ones (Sonar et al., 2004). The title compound, (I), was prepared by base-catalyzed condensation of 2-methoxybenzaldehyde with 1-azabicyclo[2.2.2]octan-3-one, to afford (Z)-2-(2-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one as a single geometrical isomer. In order to confirm the doublebond geometry, and determine how the molecular conformation in the crystal structure is affected by the position of the ortho-methoxy group, the X-ray analysis of this isomer has been carried out, and the results are presented here.