T. Ishihara, Seiji Miwatashi, M. Kuroboshi*
Feb 18, 1991
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 2-[(Trimethylsilyl)methyl]-3-chloro-3,3-difluoropropene, readily prepared in two steps from methyl chlorodifluoroacetate and (trimethylsilyl)methylmagnesium chloride, is reduced to couple regioselectivity with a variety of carbonyl compounds in the presence of zinc-copper(I) chloride or -silver acetate to give 2,2-difluoro-3-[(trimethylsilyl)methyl]-3-buten-1-ol derivatives in good to excellent yields.