Hala A. El-Asmy, I. Butler, Zhor Senhaji Mouhri
Feb 5, 2014
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Influential Citations
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Journal
Journal of Molecular Structure
Abstract
Abstract New complexes of 2-(2′-hydroxy-5′-methylphenyl)-benzotriazole (Hhmbt), [Zn(hmbt) 2 (H 2 O) 2 ], [Zn(hmbt)(OAc)(H 2 O) 2 ], [Pd(hmbt)(H 2 O)Cl], [Pd(hmbt) 2 ], [M(PPh 3 )(hmbt)Cl], [M(L)(hmbt)]Cl (M(II) = Pd, Pt; L = bpy, phen), [Ag 2 (hmbt) 2 ], [Ag(phen)(hmbt)], [Ag(PPh 3 )(hmbt)], [Rh(hmbt) 2 (H 2 O) 2 ]Cl, [Ru(hmbt) 2 (H 2 O) 2 ], [Ru(PPh 3 )(hmbt) 2 Cl] and cis -[MoO 2 (hmbt) 2 ] have been synthesized. They have been structurally and spectroscopically characterized on the basis of elemental analysis, IR, NMR ( 1 H, 13 C, 31 P), UV–vis. and ESI-mass spectroscopy, thermal and molar conductivity measurements. 2-(2′-Hydroxy-5′-methylphenyl)-benzotriazole behaves as a mononegative bidentate through the deprotonated phenolic oxygen and imine nitrogen atoms. The reported complexes have been tested against human breast cancer (MDA-MB231) and human ovarian cancer (OVCAR-8) cell lines. The complexes, [Ag(hmpbt)(PPh 3 )], [Rh(hmbt) 2 (H 2 O) 2 ]Cl, [Pt(phen)(hmbt)]Cl and [Pd(phen)(hmbt)]Cl exhibit the highest growth inhibitory activity with mean IC 50 values 1.37, 7.52, 5.24 and 4.85 μM (MDA-MB231) and 1.75, 8.50, 3.00 and 2.99 μM (OVACAR-8), respectively.