Searched over 200M research papers for "antibiotic resistance"
10 papers analyzed
These studies suggest that antibiotic resistance is a complex, natural, and evolving global public health threat driven by genetic changes and horizontal gene transfer in bacteria, requiring urgent action, novel treatments, and comprehensive management strategies.
18 papers analyzed
Antibiotic resistance is a significant global health crisis, characterized by the ability of bacteria to withstand the effects of antibiotics that once killed them or inhibited their growth. This phenomenon complicates the treatment of infectious diseases and poses a severe threat to public health.
Mechanisms of Resistance:
Genetic Basis and Evolution:
Historical and Natural Occurrence:
Clinical and Public Health Impact:
Challenges and Measurement:
Antibiotic resistance is a multifaceted issue involving various mechanisms by which bacteria evade antibiotics, driven by genetic mutations and horizontal gene transfer. This resistance is ancient and naturally occurring, exacerbated by modern antibiotic use. The clinical impact is severe, with multidrug-resistant bacteria posing significant treatment challenges. Effective management requires a comprehensive understanding of resistance mechanisms, improved measurement techniques, and innovative therapeutic strategies.
Most relevant research papers on this topic