Central serous and h pylory, what are the relationship?
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Relationship Between Central Serous Chorioretinopathy and Helicobacter Pylori
Introduction to Central Serous Chorioretinopathy (CSR)
Central Serous Chorioretinopathy (CSR) is a condition characterized by the detachment of the central retina, often affecting young males. The exact cause of CSR remains unclear, but it is known to involve the accumulation of fluid under the retina, leading to visual impairment1 2 3.
Helicobacter Pylori: A Common Gastrointestinal Infection
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that is a prevalent cause of gastrointestinal infections worldwide. It has been linked to various systemic diseases, including several eye conditions5 6.
Higher Prevalence of H. Pylori in CSR Patients
Multiple studies have demonstrated a significantly higher prevalence of H. pylori infection in patients with CSR compared to control groups. For instance, a study in Al-Diwaniya province found that 75.8% of CSR patients were infected with H. pylori, compared to 48.8% in the control group, indicating a strong association between the two conditions1. Similarly, research conducted in Iran showed an 85.7% infection rate in CSR patients versus 55.1% in controls, further supporting this link2.
Odds Ratios and Statistical Significance
The odds ratios from various studies highlight the increased risk of CSR in individuals with H. pylori infection. For example, one study reported an odds ratio of 3.29, suggesting that CSR patients are over three times more likely to have H. pylori infection than those without CSR1. Another study found an odds ratio of 4.895, reinforcing the significant association between H. pylori and CSR2. A meta-analysis also confirmed that H. pylori infection is a significant risk factor for CSR, with an odds ratio of 3.127.
Pathophysiological Hypotheses
Several hypotheses have been proposed to explain the relationship between H. pylori and CSR. One theory suggests that H. pylori may cause vascular abnormalities, such as localized vasoconstriction and impaired fibrinolysis, leading to choroidal microcirculation issues and subsequent retinal detachment4. Another hypothesis involves an immune mechanism where molecular mimicry between H. pylori antigens and host proteins could trigger endothelial dysfunction, contributing to CSR development4.
Potential for Treatment and Further Research
The potential for treating CSR by eradicating H. pylori has been suggested, with some studies reporting improvements in retinal findings and visual acuity following successful H. pylori eradication4. However, more extensive, multicenter, randomized controlled trials are needed to confirm the role of H. pylori eradication in CSR treatment and prognosis6 9.
Conclusion
The relationship between Central Serous Chorioretinopathy and Helicobacter pylori infection is supported by multiple studies showing a higher prevalence of H. pylori in CSR patients. The exact mechanisms linking the two conditions are still under investigation, but the current evidence suggests that H. pylori infection could be a significant risk factor for CSR. Further research is necessary to explore the potential benefits of H. pylori eradication in managing CSR and to better understand the underlying pathophysiological mechanisms.
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Most relevant research papers on this topic
The relation between Helicobactor pylori gastrointestinal tract infection and central serous chorioretinopathy among patients in Al-Diwaniya province
H. pylori infections are significantly associated with central serous chorioretinopathy development in young patients.
Observational StudyAssociation of Helicobacter pylori with central serous chorioretinopathy in Iranian patients
H. pylori infection is significantly higher in patients with central serous chorioretinopathy (CSR) than in controls, with no significant effect of age or sex on H. pylori test results.
Central Serous Chorioretinopathy and Helicobacter Pylori
The prevalence of Helicobacter pylori infection is significantly higher in patients with central serous chorioretinopathy (CSC) than in controls, suggesting it may be a risk factor for CSC.
Observational Study
Highly CitedAssociation of Helicobacter pylori with central serous chorioretinopathy: hypotheses regarding pathogenesis.
Helicobacter pylori infection may play a role in central serous chorioretinopathy, potentially leading to a novel antimicrobial approach or vaccine therapy.
Helicobacter pylori as a risk factor for central serous chorioretinopathy: Literature review.
Helicobacter pylori may be a risk factor for central serous chorioretinopathy (ICSCR), a potentially treatable eye disease in which the retina detaches from the macula and affects vision.
Literature ReviewPrevalence of Helicobacter pylori Infection in Patients with Central Serous Chorioretinopathy: A Review
The prevalence of Helicobacter pylori infection is significantly higher in patients with central serous chorioretinopathy (CSR), suggesting that treatment of H. pylori infection should be considered.
Systematic ReviewRISK FACTORS FOR CENTRAL SEROUS CHORIORETINOPATHY: A Systematic Review and Meta-Analysis
Hypertension, H. pylori infection, steroid usage, sleeping disturbances, autoimmune disease, psychopharmacologic medication use, and Type-A behavior are potential risk factors for central serous chorioretinopathy.
Meta-Analysis
Rigorous JournalHighly CitedIncidence of Helicobacter pylori in central serous chorioretinopathy: a case control study
The prevalence of H. pylori infection is not higher in patients with central serous chorioretinopathy (CSCR) than in controls.
Observational Study[Helicobacter pylori in central serous chorioretinopathy and diffuse retinal epitheliopathy. Results of the first prospective pilot study].
H. pylori infection is found in 56.3% of patients with long-lasting central serous chorioretinopathy and diffuse retinal epitheliopathy, suggesting a possible association between the two conditions.
Observational StudyClinical efficiency of Helicobacter pylori eradication in the treatment of patients with acute central serous chorioretinopathy
Helicobacter pylori eradication effectively reduces disease duration and recurrence frequency in patients with acute central serous chorioretinopathy, improving visual acuity and distant prognosis.
RCT