4 papers analyzed
These studies suggest that CFTR expression in human lung cells is developmentally regulated, peaks in the second trimester, and is crucial for respiratory epithelium differentiation, with potential therapeutic implications for cystic fibrosis.
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a chloride ion channel crucial for maintaining fluid balance in various tissues, including the lungs. Understanding its expression and regulation in human lung cells is essential for developing effective therapies for cystic fibrosis (CF).
Developmental Regulation of CFTR Expression:
CFTR and Inflammation:
Tissue-Specific Expression:
Inducible CFTR Expression System:
CFTR expression in human lung cells is developmentally regulated, with the highest levels observed during the second trimester. CFTR dysfunction is associated with increased inflammation, which can be mitigated by CFTR modulators. Tissue-specific expression patterns of CFTR align with the clinical symptoms of CF, and inducible expression systems offer promising tools for further research and therapy development.
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