6 papers analyzed
Some studies suggest that larger fiber diameters and pore sizes enhance cell viability, while other studies indicate that increasing overall porosity and interconnectivity can reduce cell viability.
Nanofibre scaffolds are widely used in tissue engineering due to their structural similarity to the extracellular matrix. One critical aspect of these scaffolds is their porosity, which can significantly influence cell viability. This synthesis aims to explore the correlation between nanofibre porosity and cell viability based on findings from multiple research papers.
Impact of Pore Size and Porosity on Cell Viability:
Material and Structural Properties:
Surface Modifications and Nanostructures:
Long-term Viability and Scaffold Degradation:
The correlation between nanofibre porosity and cell viability is evident across multiple studies. Larger pore sizes and higher overall porosity generally enhance cell viability by improving nutrient and waste exchange. However, the specific material properties and structural characteristics of the nanofibres also play a crucial role. Surface modifications, such as the addition of carbon nanotubes, can further enhance cell viability. These findings underscore the importance of optimizing nanofibre porosity and structural properties to improve cell viability in tissue engineering applications.
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