6 papers analyzed
These studies suggest that the firing pattern of place cells in rodent CA1 is determined by a combination of non-identical inputs, CA3 and entorhinal inputs, inhibition, theta modulation, recent experience, current cues, and spatial behavior.
Place cells in the CA1 region of the rodent hippocampus are neurons that fire when the animal is in a specific location, playing a crucial role in spatial navigation and memory. Understanding what determines the firing patterns of these place cells is essential for comprehending how spatial information is encoded in the brain.
Combinatorial Input Selection:
Role of CA3 and Entorhinal Inputs:
Hebbian Learning and Synaptic Plasticity:
Influence of Environmental Cues and Experience:
Route-Dependent Firing:
Spatial Information Encoding:
The firing patterns of place cells in the rodent CA1 region are determined by a complex interplay of factors, including the combinatorial selection of excitatory inputs, the balance of inputs from CA3 and the entorhinal cortex, synaptic plasticity mechanisms like STDP, environmental cues, and the animal's recent experiences. Additionally, place cells encode spatial information in a route-dependent manner, aiding in spatial discrimination and navigation.
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