10 papers analyzed
Some studies suggest aspartame may increase cancer risk in rodents and potentially explain increased brain tumor incidence, while other studies indicate no significant carcinogenic effects in humans or rodents at current consumption levels.
18 papers analyzed
Aspartame is a widely used artificial sweetener found in numerous food products globally. Its safety has been a topic of debate, particularly concerning its potential carcinogenic effects. This synthesis aims to analyze the existing research to determine whether aspartame causes cancer.
Rodent Studies Indicating Carcinogenicity:
Rodent Studies Not Supporting Carcinogenicity:
Human Epidemiological Studies:
Meta-Analytic Reviews:
Mechanistic Studies:
The research on aspartame and cancer presents mixed results. While some rodent studies indicate a potential carcinogenic effect, particularly with lifelong and prenatal exposure, other rodent studies and extensive human epidemiological studies do not support a significant association between aspartame consumption and cancer risk. Overall, the weight of evidence from human studies suggests that aspartame is not a significant carcinogen at current consumption levels. Further research, particularly long-term human studies, may be needed to fully resolve these discrepancies.
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