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Some studies suggest hydroxychloroquine shows potential in treating COVID-19, while other studies indicate it does not prevent infection, severe outcomes, or improve clinical scores, and may even increase risks.
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Hydroxychloroquine (HCQ) has been widely discussed as a potential treatment and prophylactic agent for COVID-19. This synthesis aims to evaluate the effectiveness of HCQ in preventing and treating COVID-19 based on data from multiple research studies.
Effectiveness in Postexposure Prophylaxis:
Effectiveness in Treating Hospitalized Patients:
Viral Clearance:
Safety and Adverse Effects:
In Vitro and Animal Studies:
The collective evidence from multiple studies indicates that hydroxychloroquine is not effective in preventing COVID-19 after exposure or in treating hospitalized patients with the disease. While some studies suggested potential benefits in viral clearance, these findings are inconsistent and often methodologically flawed. Additionally, HCQ is associated with a higher incidence of adverse effects, particularly cardiac issues. Therefore, the use of hydroxychloroquine for COVID-19 treatment or prophylaxis is not supported by the current body of evidence.
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