Effect biotin in xylitol production

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Consensus Meter

Yes65%

Possibly24%

No12%

Effect of Biotin on Xylitol Production

Biotin Limitation and Xylitol Production in Pachysolen tannophilus and Candida guilliermondii

Biotin plays a crucial role in the metabolic pathways of various microorganisms, influencing the production of ethanol and xylitol. In the case of Pachysolen tannophilus and Candida guilliermondii, the relative amounts of ethanol and xylitol produced from d-xylose are significantly affected by the extent of biotin limitation. When biotin is abundant, P. tannophilus tends to produce more ethanol compared to xylitol, whereas C. guilliermondii favors xylitol production. However, as biotin becomes limited, both organisms show an increased ratio of ethanol to xylitol production. This indicates that biotin availability can be a critical factor in controlling the balance between ethanol and xylitol production in these species.

Biotin and Xylitol Production in Candida tropicalis

In Candida tropicalis, biotin also plays a significant role in xylitol production. Research has shown that the presence of biotin, along with thiamine, is essential for the growth of C. tropicalis. Interestingly, when biotin is the sole vitamin present in the medium, the growth of C. tropicalis is reduced compared to a complete medium. However, the amount of xylitol produced is significantly higher under these conditions. This suggests that while biotin is necessary for optimal growth, its presence alone can enhance xylitol production, potentially by redirecting metabolic pathways towards xylitol synthesis rather than biomass accumulation.

Conclusion

Biotin significantly influences xylitol production in various yeast species. In Pachysolen tannophilus and Candida guilliermondii, biotin limitation increases the ethanol to xylitol production ratio, while in Candida tropicalis, biotin presence alone boosts xylitol production despite reduced growth. These findings highlight the importance of biotin in optimizing xylitol production, which could be leveraged in industrial applications to enhance yield efficiency.