10 papers analyzed
These studies suggest that grape seed extract is generally safe for consumption and may offer various health benefits.
13 papers analyzed
Grape Seed Extract (GSE) is derived from the seeds of grapes and is known for its rich content of proanthocyanidins and other polyphenolic compounds. It is widely used as a dietary supplement due to its potential health benefits, including antioxidant, anti-inflammatory, and cardioprotective effects. However, the safety of GSE, especially with long-term use and at various dosages, is a critical concern that has been addressed in multiple studies.
General Safety and Toxicity
Mutagenicity and Genotoxicity
Effects on Metabolic Health
Health Benefits and Applications
The collective evidence from multiple studies indicates that Grape Seed Extract (GSE) is generally safe for consumption, with no significant toxicological effects observed in both animal and human studies at various dosages. While some minor changes in serum iron levels and slight mutagenicity at high doses were noted, these findings were within normal ranges and warrant further investigation. Overall, GSE is well-tolerated and offers numerous health benefits, making it a viable option for use in dietary supplements and functional foods.
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