10 papers analyzed
These studies suggest microRNAs are related to neurodegenerative diseases, playing roles in molecular mechanisms, neuroplasticity, oxidative stress, and offering potential as therapeutic targets and biomarkers.
17 papers analyzed
MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. Recent research has increasingly highlighted the involvement of miRNAs in the pathogenesis of various neurodegenerative diseases (NDDs), such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). This synthesis aims to provide a cohesive overview of the current understanding of the relationship between miRNAs and neurodegenerative diseases.
Dysregulation of miRNAs in Neurodegenerative Diseases:
Role in Pathogenesis:
Potential as Biomarkers and Therapeutic Targets:
Common Pathways and Molecular Mechanisms:
The collective research underscores the significant role of miRNAs in the pathogenesis of neurodegenerative diseases. Dysregulated miRNAs are not only involved in key neurodegenerative processes but also hold potential as biomarkers and therapeutic targets. Understanding the common pathways and molecular mechanisms regulated by miRNAs could pave the way for novel therapeutic approaches to combat these debilitating diseases.
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