How much Hemp CBD should I take daily?

Introduction

Cannabidiol (CBD) is a compound found in cannabis plants that has been gaining attention for its potential health benefits, including its use as a supplement for humans and animals. Research into the appropriate dosing and long-term effects of CBD is ongoing, with studies exploring its safety, efficacy, and impact on various health measures.

Key Insights from Research Papers

A daily oral dose of 4 mg of CBD per kilogram of body weight (BW) is well-tolerated in clinically healthy dogs over a 6-month period, with no clinically significant alterations in a comprehensive suite of physiological health measures, apart from a transient elevation in alkaline phosphatase (ALP) which did not adversely affect health and wellbeing.
In humans with primary insomnia, a nightly dose of 150 mg of CBD did not significantly outperform a placebo in reducing insomnia severity or affecting cognitive performance, suggesting that while CBD may have potential as a sleep aid, its effectiveness at this dosage is comparable to placebo.

Conclusion

The research indicates that CBD can be tolerated in long-term daily dosing, at least in dogs, at a rate of 4 mg/kg BW. However, in humans with insomnia, a daily dose of 150 mg did not show a significant difference from a placebo in improving sleep or cognitive functions. These findings suggest that while CBD is generally well-tolerated, its effective dosage for specific conditions in humans may vary and requires further investigation.

Try another search

How much Astragalus should I take daily?

How much Vitamin B3 (Niacin) should I take daily?

The ethics and societal implications of workplace monitoring, employee surveillance, and the balance between organizational efficiency, privacy, and worker rights in the context of digital workplace technologies, remote work, and the increasing use of surveillance tools in monitoring employee productivity, behavior, and well-being.

What are the symptoms of food poisoning?

Is Omega-3 Fatty Acids (High Dose) safe?

How is diabetes managed?

How much Hemp CBD should I take daily?

Summary

Introduction

Key Insights from Research Papers

Conclusion

Sources and full results

Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs

A once-daily oral dose of 4 mg CBD/kg BW is well-tolerated in clinically healthy dogs for a duration of 6-months, with no adverse effects on health and wellbeing.

O049 Insomnia severity and cognitive performance following two weeks’ nightly supplementation with 150mg Cannabidiol (CBD) for primary insomnia

Daily CBD supplementation (150mg) reduced insomnia severity from moderate to subthreshold levels without affecting higher-order cognitive performance.

Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats

CBD-rich hemp nutraceuticals are safe for healthy adult dogs, but cats show lower absorption and more adverse effects during oil administration.

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain.

CBD, especially liposomal formulations, shows potential in relieving canine osteoarthritis pain and increasing mobility without significant adverse effects.

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

CBD oral solution is generally well-tolerated, with diarrhea, nausea, headache, and somnolence being the most common adverse events, and its pharmacokinetics are generally well-defined.

Serum Cannabinoid 24 h and 1 Week Steady State Pharmacokinetic Assessment in Cats Using a CBD/CBDA Rich Hemp Paste

A CBD/CBDA rich hemp paste in a palatable oral paste effectively absorbed cannabinoids in cats, with acidic forms absorbing better than non-acidic forms, and short-term treatment was safe.

A Randomized, Double-Blind, Placebo-Controlled Study of Daily Cannabidiol for the Treatment of Canine Osteoarthritis

CBD, especially liposomal formulations, shows potential in reducing pain and increasing mobility in dogs with osteoarthritis, with no significant adverse effects observed.

Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD)

CBD oil did not add value to the reduction in symptom distress provided by specialist palliative care alone in advanced cancer patients.

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model

CBD exhibits clear signs of hepatotoxicity, possibly of a cholestatic nature, raising concerns about potential drug interactions and CBD's safety.

THC and CBD blood and brain concentrations following daily administration to adolescent primates.

THC blood levels and metabolites remain stable in adolescent monkeys after daily dosing for four months, suggesting no pharmacological interactions between CBD and THC.

Try another search