How much Vitamin B6 (Pyridoxine) should I take daily?

Introduction

Vitamin B6, also known as pyridoxine, is an essential nutrient that plays a vital role in a wide range of physiological functions. Determining the appropriate daily intake of vitamin B6 is important for maintaining health, especially in different populations with varying needs.

Key Insights from Research Papers

Oral contraceptive users may require a higher intake of vitamin B6, with studies suggesting an intake between 1.5 and 5.0 mg/day to be adequate, compared to 1.5 mg/day for non-users .
The human body stores only a small amount of vitamin B6, and deficiency can occur quickly; supplementation of 1.5 mg/day has been shown to correct deficiencies.
The availability of vitamin B6 from an average American diet was found to be between 61 to 81%, with a daily intake of 1.7 to 5.8 mg/day of available vitamin B6 being typical.
High doses of vitamin B6, such as 1000 mg per day or more, can cause neuropathy, and intakes of 100-300 mg per day have occasionally been reported to be toxic; the safe upper limit is set at 100 mg per day .
Age differences in vitamin B6 status have been observed, with older adults showing a decrease in plasma pyridoxal phosphate levels; supplementation may be necessary to maintain adequate levels.
In patients with chronic renal failure or those undergoing dialysis, a daily supplement of 10 mg of pyridoxine hydrochloride is recommended to correct vitamin B6 deficiency.
For pregnant patients, especially those on isoniazid therapy, supplementation with 52 to 60 mg per day of vitamin B6 is suggested to maintain adequate pyridoxal phosphate concentrations.

Conclusion

The daily requirement for vitamin B6 varies depending on individual circumstances such as the use of oral contraceptives, age, and specific health conditions like renal failure or pregnancy. For most adults, a daily intake of 1.5 mg is sufficient to prevent deficiency, while oral contraceptive users may need between 1.5 and 5.0 mg/day. It is important to avoid excessive intake, as high doses can lead to toxicity and neuropathy, with the safe upper limit being 100 mg per day. Special populations, such as those with chronic renal failure or pregnant women on certain medications, may require higher doses to maintain adequate levels.

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How much Vitamin B6 (Pyridoxine) should I take daily?

Summary

Introduction

Key Insights from Research Papers

Conclusion

Sources and full results

The vitamin B6 requirement in oral contraceptive users. I. Assessment by pyridoxal level and transferase activity in erythrocytes.

An intake between 1.5 and 5.0 mg/day of vitamin B6 is adequate for oral contraceptive users, compared to 1.5 mg/day previously recommended for nonusers.

Biochemical assessment of the nutritional status of vitamin B 6 in the human.

Vitamin-B6 deficiency can quickly lead to low blood plasma levels, and a daily supplement of 1.5 mg of pyridoxine can correct this issue.

Availability of vitamin B6 and pantothenate in an average American diet in man.

The average American diet contains 1.7 and 5.8 mg/day of available vitamin B6 and pantothenate, respectively, with varying levels of availability based on plasma pyridoxal phosphate and urinary data.

The vitamin B6 requirement in oral contraceptive users. II. Assessment by tryptophan metabolites, vitamin B6, and pyridoxic acid levels in urine.

1.5 mg of vitamin B6 is sufficient for most oral contraceptive users, with no significant difference in vitamin B6 requirement between users and nonusers.

Vitamin B6 Safety Issues

High-dose pyridoxine is safe for long-term use, but long-term intake of 200 mg/day may be considered safe, with recent data showing no teratogenicity in humans or animals.

Age differences in vitamin B6 status of 617 men.

Vitamin B6 status in men ages 18 to 90 decreases by 0.9 ng/ml per decade, with a significant decrease in plasma pyridoxal phosphate levels in men over age 80.

[How much vitamin B6 is toxic?].

High intakes of vitamin B6 can cause neuropathy, with the safe upper limit at 100 mg per day, but physicians should be alert to high intakes as a potential cause of unexplained neuropathy.

Daily requirement for pyridoxine supplements in chronic renal failure.

A daily dose of 10 mg/day of pyridoxine hydrochloride is recommended for patients on hemodialysis, 5.0 mg/day for peritoneal dialysis, and 4.1 mg/day for chronic renal failure patients.

Hoeveel vitamine B6 is toxisch

High intakes of vitamin B6 can cause neuropathy, with the safe upper limit being 100 mg per day, but physicians should be alert to high intakes as a cause of unexplained neuropathy.

Maternal plasma concentration of pyridoxal phosphate during pregnancy: adequacy of vitamin B6 supplementation during isoniazid therapy.

Vitamin B6 supplementation with 52 to 60 mg per day provides adequate pyridoxal phosphate concentrations in pregnant patients receiving isoniazid therapy.

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