How much Vitamin D should I take daily?

Vitamin D is essential for maintaining healthy bones and a well-functioning immune system. The optimal daily intake of vitamin D to maintain sufficient blood levels is a subject of ongoing research and debate.

Infants may require a daily supplementation dose of 400 IU to avoid vitamin D deficiency and rickets, as this dose was shown to significantly increase median levels of 25-hydroxyvitamin D3 compared to a 200 IU dose.
For adults, a daily dose of 4600 IU may be optimal to achieve a serum 25-hydroxyvitamin D concentration greater than 75 nmol/L, which is suggested to be sufficient for bone health.
The Tolerable Upper Intake Level (UL) for vitamin D has been set at 100 µg/day (4000 IU) for adults, including pregnant and lactating women, and at 50 µg/day (2000 IU) for children aged 1-10 years, with no observed adverse effects at these levels.
Achieving serum 25-hydroxyvitamin D concentrations of 80 nmol/L or higher may require daily oral intakes of 2200 IU or more, depending on individual starting levels and cutaneous synthesis.
A daily supplementation of 800 IU vitamin D in nursing home residents was sufficient to achieve vitamin D sufficiency (serum 25(OH)D ≥ 50 nmol/L) in the majority of cases.
The US Institute of Medicine recommends a minimal intake of 600 IU daily for adults over 70 years old, but intakes up to 4000 IU daily are considered safe.
Long-term care residents may be at high risk for vitamin D deficiency and should receive a minimum daily supplement of 800 IU.
For breastfed infants in Montreal, Canada, a daily dose of 400 IU vitamin D was sufficient to meet the plasma 25-hydroxyvitamin D threshold of 50 nmol/L but not 75 nmol/L by 12 months of age.

In conclusion, the daily intake of vitamin D varies depending on age, health status, and individual requirements. Infants may benefit from a daily dose of 400 IU, while adults may require higher doses, with 4600 IU suggested to achieve optimal serum concentrations for bone health. The Tolerable Upper Intake Level for adults is set at 4000 IU, and long-term care residents should receive at least 800 IU daily to prevent deficiency. It is important to consider individual variability and consult with healthcare providers to determine the appropriate vitamin D intake for specific needs.

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How much Vitamin D should I take daily?

Summary

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Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants

Daily supplementation of 400 IU of vitamin D in infants is a safe and effective dose to prevent vitamin D deficiency and rickets.

Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration.

Optimal daily vitamin D intake is 115 micrograms per day (4600 IU) to achieve serum 25-hydroxyvitamin D concentrations >75 nmol/L, considering variability in dose-response curves and basal levels.

Scientific Opinion on the Tolerable Upper Intake Level of vitamin D

The revised Tolerable Upper Intake Levels for vitamin D for adults, pregnant and lactating women, children and adolescents are 100 g/day for adults, 50 g/day for children aged 1-10 years, and 25 g/day for infants.

The Vitamin D requirement in health and disease

Aiming for serum 25-hydroxyvitamin D levels of 80nmol/L optimizes intestinal calcium absorption, minimizes parathyroid activity, and reduces osteoporotic fractures, with a daily oral intake of 2200IU (55microg) or more needed for optimal health.

Efficacy of daily 800 IU vitamin D supplementation in reaching vitamin D sufficiency in nursing home residents: cross-sectional patient file study

Daily 800 IU vitamin D supplementation with cholecalciferol capsules is effective in achieving vitamin D sufficiency in most nursing home residents, with major differences in efficacy between preparations.

The 2010 recommendations of the American Institute of Medicine for daily intakes of vitamin D

The 2010 US Institute of Medicine recommendation for daily vitamin D intake is 15 mg/d for adults, with up to 100mg/d as safe for healthy adults.

Vitamin D, how much is enough and how much is too much?

The US Institute of Medicine recommends 15 mg/d of vitamin D for adults, but up to 100mg/d is safe for healthy adults, and randomized controlled trials are needed to establish optimal vitamin D levels and optimal intakes for optimal health outcomes.

The same annual dose of 292000 IU of vitamin D3 (cholecalciferol) on either daily or four monthly basis for elderly women: 1‐year comparative study of the effects on serum 25(OH)D3 concentrations and renal function

Four monthly administration of vitamin D3 (97333 IU) is more effective and safe than daily dosing for elderly women, overcoming adherence challenges.

Should long-term care residents be supplemented with vitamin D?

Older people living in long-term care facilities are at high risk for vitamin D deficiency and should receive a minimum daily supplement of 800 IU to prevent deficiencies.

Vitamin D dose‐response study in breast fed infants from Montréal, Canada: 400 IU/day is sufficient to meet the plasma 25‐hydroxy vitamin D threshold of 50 nmol/L but not 75 nmol/L by 12 months of age

400 IU/day of vitamin D is sufficient to meet the 50 nmol/L threshold in breastfed infants, but not the 75 nmol/L threshold by 12 months of age.

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