nicorette spray side effects long-term use

Nicotine replacement therapies (NRTs), such as nicotine mouth sprays, are used to aid smoking cessation by reducing withdrawal symptoms and cravings associated with quitting smoking. These therapies are designed to deliver nicotine in a controlled manner to help manage the addiction while avoiding the harmful effects of tobacco smoke.

Key Insights from Research Papers:

Nicotine mouth sprays are preferred over other forms of NRT like gums and inhalers, but they are associated with a higher rate of local adverse effects such as burning of the tongue/throat, nausea, and hiccups.
Initial use of nicotine nasal sprays can cause substantial irritant side effects including runny nose, nasal irritation, throat irritation, watering eyes, and sneezing, which tend to decrease significantly within the first week of use.
Long-term use of nicotine gum, another form of NRT, shows that while it can effectively reduce symptoms of irritability, anxiety, and hunger during the first 10 weeks of cessation, the benefits for suppressing psychological distress may diminish after the first 4-5 weeks.

Conclusion:

Nicotine mouth sprays are a popular choice for smoking cessation, but they come with a notable incidence of local side effects. While these side effects are prominent, they may be tolerable or decrease over time, similar to the pattern observed with nicotine nasal sprays. Long-term use of NRTs like nicotine gum suggests that while some benefits may wane over time, they can still be helpful in managing specific withdrawal symptoms, which could be relevant for preventing relapse. Further research is needed to determine the long-term side effects of nicotine mouth sprays specifically and whether lower doses could reduce these side effects and improve compliance and success rates.

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Nicorette spray side effects long-term use

Summary

Sources and full results

A Nicotine Mouth Spray for Smoking Cessation: A Pilot Study of Preference, Safety and Efficacy

Nicotine mouth spray is preferred by smokers, but has a high rate of local adverse effects, and its efficacy is comparable to gum and inhaler.

Nicotine nasal spray for smoking cessation: pattern of use, side effects, relief of withdrawal symptoms, and cotinine levels.

Nicotine nasal spray causes irritant side effects during the first few days, but these side effects decrease significantly within the first week, leading to a high rate of initial abstinence from smoking.

Nicotine replacement: ten-week effects on tobacco withdrawal symptoms

Nicotine replacement gum effectively reduces tobacco withdrawal symptoms in the first 5 weeks after smoking cessation, but longer use may be advisable for long-term smoking relapse prevention.

Evaluation of side effects after nicotine nasal spray in patients with chronic rhinitis.

Nicotine nasal spray is a short-term safe aid in smoking cessation for patients with chronic rhinitis, with irritant nasal side effects occurring most often in the early stages of treatment.

Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial.

Nicotine nasal spray is a safe, effective, and viable alternative treatment for smoking cessation, with success rates significantly enhanced compared to placebo.

Electronic monitoring of long-term use of the nicotine nasal spray and predictors of success in a smoking cessation program.

Long-term use of nicotine nasal spray is effective in smoking cessation, with abstinence during the first two weeks being significantly associated with success at 6 months and 24 months.

Dependence potential of nicotine replacement treatments: effects of product type, patient characteristics, and cost to user.

Long-term use of nicotine replacement treatment is common, particularly among highly dependent smokers, and may be a necessary precondition for maintaining long-term abstinence.

Recycling of hard-core smokers with nicotine nasal spray.

Long-term success rate with nicotine nasal spray for hard-core smokers is low, with no significant difference between ad libitum and fixed dosing.

COMING OFF LONG-TERM NICOTINE GUM

Long-term nicotine gum users can wean themselves off by using inactive nicotine gum, despite potential reinforcing of nicotine dependency.

A randomized trial of the effects of two novel nicotine replacement therapies on tobacco withdrawal symptoms and user satisfaction.

Mouth spray and lozenge are as effective as 4 mg nicotine gum in relieving cravings, suggesting they are likely to aid smoking cessation.

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