Is Peptide Supplements safe?

Introduction

Peptide supplements, particularly bioactive peptides, have gained popularity for their potential health benefits, including improved muscular performance, immune function, and overall health. However, the safety of these supplements remains a critical concern, necessitating thorough evaluation.

Key Insights

General Safety and Tolerability:
- Bioactive peptides are generally considered safe and well-tolerated when consumed within recommended dosages .
- Commercially available bioactive peptide supplements, such as Bio-GroTM, have shown no adverse effects on blood markers of health and organ function in men engaged in intense resistance training.
Safety of Protein Hydrolysates and Fractions:
- Protein hydrolysates and their fractions, including bioactive peptides, are safe provided the proteolytic enzymes used are food grade and of suitable quality.
- The safety of these products should be assessed by companies before market introduction, especially if novel protein sources or production processes are used.
Potential Risks and Toxicity:
- There is a potential for the formation of allergenic and toxic peptides during the hydrolysis of food proteins.
- Some naturally occurring peptides and enzymes may induce high toxicity, including intestinal wall disruption and cytotoxicity.
- The safety of bioactive peptides can be affected by administration dosage and length of use.
Specific Case Studies:
- A novel milk protein peptide mixture was found to be safe in a six-week study involving healthy volunteers, with no significant side effects and all clinical blood markers remaining within normal levels.
- Whey protein peptides are generally safe for use in functional foods, though specific purified peptides should be carefully evaluated before high-quantity use.
Regulatory and Safety Assessment:
- Good judgment on the safety of hydrolysates and their fractions can be obtained by comparing anticipated amino acid intake with levels expected from a balanced diet.
- External safety evaluations and regulatory approvals are necessary for novel protein hydrolysates before market introduction.

Conclusion

Peptide supplements, particularly bioactive peptides, are generally safe and well-tolerated when consumed within recommended dosages. However, potential risks such as allergenicity and toxicity must be carefully evaluated, especially for novel peptides or those produced through new processes. Regulatory oversight and thorough safety assessments are crucial to ensure consumer safety.

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Is Peptide Supplements safe?

Summary

Consensus Meter

Introduction

Key Insights

Conclusion

Sources and full results

Safety and organ health with 8 weeks use of commercially available bio-active peptide supplement: A prospective, double-blind, placebo controlled randomized trial

Bio-GroTM, a commercial bio-active peptide supplement, showed no significant adverse effects on blood markers of health and organ function in men engaged in intense resistance training.

Peptide therapeutics: current status and future directions.

Peptides are highly selective, efficacious, and relatively safe, with new approaches like multifunctional and cell penetrating peptides emerging for future peptide drug design and development.

Safety of protein hydrolysates, fractions thereof and bioactive peptides in human nutrition

Protein hydrolysates and fractions, including bioactive peptides, are safe for human consumption when applied with food-grade enzymes and a history of safe use.

Bioactive milk peptides: a prospectus.

Bioactive milk peptides show potential for dietary supplements, pharmaceuticals, and food products, potentially improving consumer safety and providing therapeutic value for treatment or prevention of diseases.

Safety considerations on food protein-derived bioactive peptides

Food protein-derived bioactive peptides may release potential toxic and allergenic peptides, and their safety is affected by administration dosage, frequency, and length of use.

Bioactive properties and clinical safety of a novel milk protein peptide

Novel milk protein peptide shows potential anti-cancer properties and is safe to consume orally, warranting further clinical studies for improving quality of life and outcomes in cancer patients.

Bioactivity and safety of whey peptides

Whey protein peptides can be safely used as food ingredients for functional foods, but specific purified whey peptides should be carefully evaluated for high-quantity use.

Identification of the growth-hormone-releasing peptide-2 (GHRP-2) in a nutritional supplement.

GHRP-2, a growth-hormone-releasing peptide, was identified and quantified in over-the-counter nutritional supplements, potentially enhancing performance in elite sports and posing a risk to healthy individuals.

Safety of milk‐derived bioactive peptides

Milk-derived bioactive peptides show potential health benefits but require further safety evaluations due to potential allergenicity, cytotoxicity, genotoxicity, and mutagenicity.

Toxicity of Biologically Active Peptides and Future Safety Aspects: An Update.

Biologically active peptides play a beneficial role in various industries, but their safety must be evaluated before their use in food and pharmaceutical applications due to potential immunogenicity and toxicities.

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