Is Phenibut safe?
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Research Analysis by Consensus
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Yes0%
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Introduction
Phenibut is a psychoactive substance that acts on GABAB receptors and has been used for its anxiolytic and nootropic effects. Its safety profile has been questioned due to reports of dependence, intoxication, and withdrawal symptoms, particularly when obtained online and used in doses exceeding recommended therapeutic levels.
Key Insights from Research Papers
- Phenibut is generally safe and well-tolerated at therapeutic doses, with minor adverse effects such as somnolence reported in only 5.66% of patients in clinical trials; however, higher doses and online purchases have been associated with dependence and intoxication.
- There is a growing concern over phenibut's potential for physical dependence, withdrawal, and addiction, with case reports indicating severe intoxication and mental status changes in users .
- Self-directed detoxification using phenibut can lead to serious risks, including altered mental status and severe withdrawal symptoms, as highlighted by case reports during the COVID-19 pandemic.
- F-phenibut, a derivative with higher affinity for GABAB receptors, may lead to more serious intoxication than phenibut, suggesting a potential for severe damage by inhibiting neuronal excitability.
- Despite FDA warnings, the quantity of phenibut in over-the-counter supplements has increased, with some doses exceeding those of pharmaceutical tablets manufactured in Russia, raising concerns about the potential for toxicity.
- Phenibut's availability as an unregulated "dietary supplement" is misleading, given its potent psychoactive effects and the risk of adverse outcomes such as lethargy, delirium, psychosis, and coma .
Conclusion
While phenibut can be safe at therapeutic doses under clinical supervision, there is substantial evidence of its potential for abuse, dependence, and serious adverse effects, especially when used in high doses or obtained from unregulated online sources. The discrepancy between the safety profile in clinical settings and the risks associated with recreational use or self-medication underscores the need for caution and regulation.
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