10 papers analyzed
These studies suggest that senna is generally safe and effective for treating constipation and has additional antioxidant properties, though prolonged use may cause melanosis coli.
8 papers analyzed
Senna is a commonly used herbal laxative derived from the leaves and fruits of the Cassia plant species. It is widely utilized for treating constipation in various populations, including children, adults, and the elderly. Despite its popularity, concerns about its safety, especially with long-term use, have prompted numerous studies to evaluate its potential side effects and overall safety profile.
General Safety and Side Effects:
Specific Populations:
Carcinogenicity and Genotoxicity:
Efficacy in Special Conditions:
Senna is a safe and effective laxative for treating constipation across various populations, including children and the elderly, when used in recommended doses. While minor gastrointestinal side effects are common, they are generally manageable. Long-term use does not appear to pose significant health risks, including carcinogenicity. However, high doses can lead to rare side effects such as perineal blistering in children. Overall, Senna remains a reliable option for managing constipation, with a well-established safety profile.
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