CD-TREAT is an easier-to-comply, more acceptable alternative to exclusive enteral nutrition for patients with active Crohn's disease, potentially improving gut microbiome changes and reducing inflammation.

Treatment of Active Crohn's Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral Nutrition.

Antibiotics significantly improve Crohn's disease activity and may be a potential treatment option for patients, potentially leading to remission or favorable clinical response.

EFFECTIVENESS OF ANTIBIOTICS AS A TREATMENT OPTION FOR PATIENTS WITH CROHN’S DISEASE: A META ANALYSIS

Combination therapy is a strong and safe treatment approach for Crohn's disease, outweighing potential risks and becoming the standard treatment approach until gut selective therapies are better established.

Combination therapy for the treatment of Crohn’s disease

MLN0002, a dose-dependent antibody targeting alpha4beta7 integrin, shows potential in reducing clinical remission rates in patients with active Crohn's disease.

Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin.

Elemental diet is a safe and effective treatment for acute Crohn's disease, improving patients as much as and sometimes more than steroid-treated patients.

Elemental diet as primary treatment of acute Crohn's disease: a controlled trial.

Anti-TNF therapy has improved response and remission rates in Crohn's disease patients, but considerations of immunogenicity, safety, and duration of treatment are crucial for effective treatment.

Anti-TNF Therapy in Crohn’s Disease

Effective medical therapy, when used early and timely, has improved outcomes in Crohn's disease patients, reducing surgery and promoting clinical and endoscopic remission, reducing corticosteroid dependence, and preventing long-term complications.

A review of the therapeutic management of Crohn’s disease

The second European evidence-based consensus on Crohn's disease management emphasizes early use of azathioprine/mercaptopurine or methotrexate with steroids, anti-TNF therapy, and surgery as options for active disease and relapse.

The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management.

Drugs reducing transforming growth factor beta and local injections of mesenchymal stem cells show potential in treating Crohn's disease-associated bowel damage.

Treatments for Crohn's Disease–Associated Bowel Damage: A Systematic Review

Nutrition plays a crucial role in managing Crohn's disease, with recent findings highlighting the importance of a well-balanced diet and nutrigenomics.

Nutritional Treatment in Crohn’s Disease

Inflammatory bowel diseases can be effectively treated with medications, with newer therapies like infliximab and adalimumab enhancing the overlap in treatment approaches.

Treatment of inflammatory bowel disease: a review of medical therapy.

Antibiotics provide benefit for Crohn's disease, as first-line therapy or combined with immunomodulatory drugs, despite limited clinical trial evidence.

Antibiotics should be used as first-line therapy for Crohn's disease.

Crohn's disease exclusion diets can induce remission and modulate the microbiome, offering new treatment strategies for patients with refractory disease or relapsed medical therapy.

A Case-Based Approach to New Directions in Dietary Therapy of Crohn’s Disease: Food for Thought

Probiotics show insufficient evidence to determine their efficacy in inducing remission in Crohn's disease, with further research needed.

Probiotics for induction of remission in Crohn's disease.

Crohn disease is a chronic inflammatory bowel disease with variable symptoms and requires ongoing therapy, often with surgery, for disease recurrence.

Crohn Disease: Epidemiology, Diagnosis, and Management

Advances in therapeutics offer new and effective treatment options for inflammatory bowel disease, offering patients alternative options to systemic immunosuppression and pharmacological treatments.

Emerging treatments for inflammatory bowel disease

Probiotics show strong evidence in achieving or maintaining remission in ulcerative colitis patients, but more research is needed to justify their efficacy in Crohn's disease patients.

The Role of Probiotics in Inducing and Maintaining Remission in Crohn’s Disease and Ulcerative Colitis: A Systematic Review of the Literature

Immunosuppressive medications for Crohn's disease are generally safe, but concerns exist about increased risks of infections, skin cancer, and lymphoma.

Safety of drugs used for the treatment of Crohn’s disease

Crohn's disease is a progressive, destructive inflammatory bowel disease with an uncertain cause, and personalized treatment is crucial to address the underlying pathogenetic mechanisms and prevent complications.

Crohn’s disease

Manipulating gut microbiota through therapies like fecal microbiota transplant and personalized diets may provide protective effects against Crohn's disease and improve treatment outcomes.

Manipulation of Gut Microbiota as a Key Target for Crohn's Disease

What is the treatment for Crohn's disease?

These studies suggest treatments for Crohn's disease include dietary approaches (CD-TREAT, elemental diet, nutrition), medications (antibiotics, anti-TNF therapy, azathioprine/mercaptopurine, methotrexate, MLN0002), and combination therapy, with some studies also highlighting the potential of stem cell therapy and early medical intervention.