Does CBD Convert to THC in the Body?

Check out this answer from Consensus:

The current body of scientific evidence strongly suggests that CBD does not convert to THC in the human body under normal physiological conditions. While in vitro studies have shown that such conversion is possible in highly acidic environments, these conditions do not accurately reflect the human digestive system. Therefore, concerns about CBD converting to THC and causing psychoactive effects or legal issues are largely unfounded.

Cannabidiol (CBD) and tetrahydrocannabinol (THC) are two primary cannabinoids found in the cannabis plant. While THC is known for its psychoactive effects, CBD is non-psychoactive and is often used for its potential therapeutic benefits. A question that has sparked considerable debate in the scientific community is whether CBD can convert to THC in the human body. This article aims to explore the current scientific understanding of this issue by reviewing relevant research findings.

CBD and THC: An Overview

CBD and THC have distinct pharmacological profiles. THC binds to CB1 receptors in the brain, leading to its psychoactive effects, whereas CBD does not bind to these receptors and is considered non-psychoactive. Both cannabinoids can influence each other’s effects when co-administered, but their individual metabolic pathways are different.

In Vitro Studies

Several studies have investigated the potential for CBD to convert to THC under various conditions. In vitro studies have shown that CBD can convert to THC in acidic environments, such as simulated gastric fluid (SGF). However, these conditions are highly artificial and do not accurately represent the physiological conditions in the human stomach2 5 9.

In Vivo Studies

In vivo studies, which involve living organisms, provide more relevant insights. Research involving animal models, such as rats, has shown that CBD can inhibit the metabolism of THC, leading to higher levels of THC in the brain and serum. However, these studies also found that CBD alone did not convert to THC in significant amounts3 6.

Human Studies

Human studies have largely debunked the notion that CBD converts to THC in the body. A randomized, double-blind, placebo-controlled study found no evidence of CBD converting to THC after oral administration in humans. The study concluded that the conversion observed in vitro does not occur under physiological conditions1 4 5.

Pharmacokinetics and Metabolism

The pharmacokinetics of CBD and THC are complex and influenced by various factors, including the route of administration and individual metabolic differences. CBD has been shown to inhibit certain enzymes involved in the metabolism of THC, potentially altering its pharmacokinetic profile. However, this interaction does not equate to a conversion of CBD to THC1 6 8.

Legal and Forensic Implications

The potential for CBD to convert to THC has significant legal and forensic implications, especially given the increasing use of CBD products. However, current evidence suggests that such conversion is unlikely to occur in vivo, thereby minimizing concerns about false-positive drug tests for THC7 9.

Does CBD convert to THC in the body?

Federica Pollastro has answered Likely

An expert from University of Eastern Piedmont in Cannabis

CBD needs acid condition and must be completely dissolved to convert to THC in the body. This is possible only in laboratory condition.

Normally, CBD is not dissolved in stomach and in the organic fluids and the conversion in THC in gastric fluids (where pH is near 2) is minimal. Traces of THC derivatives can be detected after oral intake of CBD but, normally, are not enouth for a biological activity.

Does CBD convert to THC in the body?

Ethan Russo has answered Extremely Unlikely

An expert from International Cannabis and Cannabinoids Institute in Cannabis

This simply does not occur.