10 papers analyzed
These studies suggest that depression has a significant genetic component, with various factors such as serotonin transporter polymorphisms, mitochondrial DNA, and familial aggregation contributing to its heritability.
14 papers analyzed
Depression, particularly major depressive disorder (MDD), is a prevalent psychiatric condition with significant impacts on individuals and society. Understanding whether depression is inherited has been a focal point of numerous genetic studies. This synthesis aims to consolidate findings from various research papers to address the question: Is depression inherited?
Genetic Contribution to Depression:
Specific Genetic Factors:
Maternal Inheritance:
Gene-Environment Interactions:
Genetic Heterogeneity:
The research indicates that depression has a significant genetic component, with heritability estimates suggesting that up to 50% of the risk for developing depression can be attributed to genetic factors. Specific genetic polymorphisms and loci have been identified, though findings are often inconsistent and require further study. Additionally, gene-environment interactions and potential maternal inheritance through mtDNA contribute to the complexity of depression's genetic basis. Overall, while depression is partly inherited, it is influenced by a combination of genetic and environmental factors.
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