6 papers analyzed
These studies suggest that cancer cell metastasis involves a complex process including physical translocation, modulation by long non-coding RNAs, collective cell migration, multiple steps to specific organs, vessel formation, and dynamic adaptation of mechanical properties.
Metastasis, the spread of cancer cells from a primary tumor to distant organs, is a complex and multistep process that is responsible for the majority of cancer-related deaths. Understanding the mechanisms behind this process is crucial for developing effective treatments to prevent and combat metastatic cancer.
Epithelial-to-Mesenchymal Transition (EMT) as a Critical Step:
Role of Long Non-Coding RNAs (lncRNAs):
Collective Metastasis:
Mechanical Adaptability of Tumor Cells:
Multistep Process of Metastasis:
Metastasis is a multifaceted process involving critical steps such as EMT, the role of lncRNAs, collective metastasis, and mechanical adaptability of tumor cells. Understanding these mechanisms provides valuable insights into potential therapeutic targets and strategies to prevent and treat metastatic cancer.
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