monkey kidney

Introduction

Research on monkey kidneys spans various aspects, including transplantation techniques, developmental disorders, anatomical studies, radiation effects, and tissue engineering. This synthesis aims to consolidate key insights from multiple studies to provide a comprehensive understanding of the current state of research on monkey kidneys.

Key Insights

Kidney Transplantation Techniques:
- Improved microsurgical techniques for kidney transplantation in monkeys have been developed, showing no surgical mortality and providing a model for testing immunosuppressants and studying drug-induced tolerance.
Developmental Disorders:
- A fetal rhesus monkey model of obstructive renal dysplasia has been established, demonstrating the importance of this model for exploring congenital obstructive uropathy and highlighting the role of podocyte injury in long-term renal function.
Anatomical and Ultrastructural Studies:
- Detailed studies on the renal microvasculature of monkeys have described the complex vascular patterns and their potential physiological significance, particularly in urine concentration .
- The ultrastructure of the proximal tubule in rhesus monkey kidneys has been defined, providing comparisons with human kidneys and insights into the effects of biopsy preparation methods.
Radiation Effects:
- Research on the radiation response of monkey kidneys post-nephrectomy indicates a dose-dependent reduction in renal function and morphological changes, with higher doses leading to renal failure.
Renal Tumors:
- Cases of bilateral undifferentiated renal sarcomas in rhesus monkeys have been documented, adding to the understanding of renal tumors in nonhuman primates.
Virus Production:
- Subcultured monkey-kidney cells have been shown to have a high folic acid requirement for growth and are effective in producing poliovirus, similar to primary cultures.
Tissue Engineering:
- Decellularized rhesus monkey kidneys have been developed as three-dimensional scaffolds, retaining critical structural and functional properties necessary for renal tissue engineering and promoting cellular repopulation.

Conclusion

Research on monkey kidneys encompasses a wide range of topics, from transplantation techniques and developmental disorders to anatomical studies and tissue engineering. Improved surgical methods, detailed anatomical descriptions, and innovative tissue engineering approaches highlight the progress in this field. These studies collectively enhance our understanding of kidney function, disease, and potential therapeutic strategies in both nonhuman primates and potentially humans.

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Improved techniques for kidney transplantation in the monkey

Improved microsurgical techniques for kidney transplantation in monkeys provide a useful model for testing new immunosuppressants and investigating drug-induced tolerance and xenotransplantation in primates.

Fetal rhesus monkey model of obstructive renal dysplasia.

This fetal monkey model reveals that obstructed kidneys show features of renal dysplasia, with podocyte injury potentially playing a role in long-term renal function.

Scanning electron microscopy of human and rhesus monkey kidneys.

Scanning electron microscopy can effectively study human and rhesus monkey kidneys, potentially aiding in routine diagnosis of human biopsies.

The renal microvasculature of the monkey: an anatomical investigation.

Monkey kidneys have a complex renal microvasculature, potentially contributing to their ability to concentrate urine despite the absence of an inner medullary zone.

The renal vascular system of the monkey: a gross anatomical description.

Monkey kidneys have six to eight arterial segments, each supplied by a segmental artery, and a three-region intrarenal venous system.

Ultrastructure of the proximal tubule of the rhesus monkey kidney.

The proximal tubule of the rhesus monkey kidney shows similar ultrastructure to the human kidney, with some alterations due to the methods used for percutaneous renal biopsies.

Radiation response of the monkey kidney following contralateral nephrectomy.

Dose-dependent kidney damage in rhesus monkeys after unilateral nephrectomy leads to functional and morphological changes, with higher doses causing renal failure and lower doses causing glomerular changes and surviving animals.

Bilateral Undifferentiated Renal Sarcomas in a Rhesus Monkey

Bilateral undifferentiated renal sarcomas were diagnosed in an adult male rhesus monkey, highlighting the potential for malignant mesenchymal renal tumors in nonhuman primates.

Virus Production by Subcultured Monkey-Kidney Cells

Subcultured monkey-kidney cells with high folic acid levels can produce similar poliovirus yields as primary cultures, making them a useful tool for virus production in poliovirus research.

Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering.

Decellularized rhesus monkey kidney sections retain structural and functional properties, promoting cellular repopulation for renal tissue engineering and repair.

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