How much Gymnema sylvestre should I take daily?
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Recommended Daily Dosage of Gymnema sylvestre
Introduction to Gymnema sylvestre Benefits
Gymnema sylvestre is a medicinal plant known for its potential benefits in managing metabolic syndrome, blood glucose levels, and body weight. Research has shown that it can positively impact lipid and glucose levels, blood pressure, and body weight, making it a valuable supplement for individuals with metabolic disorders and diabetes.
Dosage for Metabolic Syndrome
A clinical trial investigated the effects of Gymnema sylvestre on metabolic syndrome (MetS) in 24 patients aged 30-60 years. Participants were given 600 mg of Gymnema sylvestre daily, divided into two doses of 300 mg each, taken before breakfast and dinner for 12 weeks. The study found significant reductions in body weight, body mass index (BMI), and very low-density lipoprotein (VLDL) levels without altering insulin secretion and sensitivity.
Key Findings:
- Daily Dosage: 600 mg (300 mg twice daily)
- Duration: 12 weeks
- Benefits: Decreased body weight, BMI, and VLDL levels
Dosage for Type 2 Diabetes
Another study focused on the antidiabetic effects of Gymnema sylvestre leaf extract (GS4) in 22 patients with non-insulin-dependent diabetes mellitus (Type 2 diabetes). Participants were administered 400 mg of GS4 daily for 18-20 months alongside their conventional oral anti-hyperglycaemic medications. The results showed significant reductions in blood glucose, glycosylated hemoglobin, and glycosylated plasma proteins. Additionally, some patients were able to reduce or discontinue their conventional medications while maintaining blood glucose homeostasis with GS4 alone.
Key Findings:
- Daily Dosage: 400 mg
- Duration: 18-20 months
- Benefits: Reduced blood glucose, glycosylated hemoglobin, and glycosylated plasma proteins; potential beta cell regeneration
Conclusion
Based on the available research, the recommended daily dosage of Gymnema sylvestre varies depending on the condition being treated. For metabolic syndrome, a dosage of 600 mg per day (300 mg twice daily) for 12 weeks has been shown to be effective. For Type 2 diabetes, a daily dosage of 400 mg over an extended period (18-20 months) has demonstrated significant benefits in blood glucose management and potential beta cell regeneration. Always consult with a healthcare provider before starting any new supplement regimen to ensure it is appropriate for your specific health needs.
Sources and full results
Most relevant research papers on this topic
Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.
Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients.
A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats.
A systematic review of Gymnema sylvestre in obesity and diabetes management.
Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre
Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance.
Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus.
[Gymnema sylvestre leaf extract: a 52-week dietary toxicity study in Wistar rats].
Acute and sub-acute toxicity profile of crude extract and fractions of Gymnema sylvestre
The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta‐analysis
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