4 papers analyzed
These studies suggest that a single dose of 25-35 mg of psilocybin may be effective for reducing depression, but daily use is not recommended due to potential adverse effects.
Psilocybin, a psychoactive compound found in certain mushrooms, is being studied for its potential therapeutic effects, particularly in treating depression. Research has focused on determining the optimal dosage and understanding its impact on cognitive and emotional functions.
Efficacy in Treating Depression:
Safety and Tolerability:
Mechanism of Action:
Research indicates that a single dose of psilocybin, particularly around 25 mg to 35 mg/70 kg, can significantly reduce depressive symptoms, especially in treatment-resistant cases. These doses are generally well tolerated with manageable side effects. The antidepressant effects may be linked to increased synaptogenesis and changes in serotonin receptor density. Further studies are needed to confirm these findings and establish long-term safety and efficacy.
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