10 papers analyzed
Some studies suggest polygenic risk scores (PRS) show promise in predicting disease risk and aiding clinical decision-making, particularly for complex disorders and personalized cancer risk, while other studies highlight the need for further development, addressing ancestry bias, and ethical considerations.
Polygenic risk scores (PRS) are emerging as a tool to estimate an individual's genetic susceptibility to various complex diseases by aggregating the effects of multiple genetic variants. While PRS have shown promise in research settings, their clinical utility and generalizability across diverse populations remain areas of active investigation.
Predictive Value and Clinical Utility:
Combination with Other Risk Factors:
Generalizability and Population Differences:
Specific Disease Applications:
Ethical, Legal, and Social Implications:
Polygenic risk scores hold promise for enhancing disease risk prediction and informing clinical decision-making. While they are increasingly being integrated into clinical practice, their utility is maximized when combined with other risk factors. Significant challenges remain in improving their generalizability across diverse populations and addressing ethical concerns. Continued research and methodological advancements are essential for realizing the full potential of PRS in personalized medicine.
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