Resveratrol memory, cognitive, mental, brain

Introduction

Resveratrol, a natural polyphenolic compound found in various fruits such as grapes and berries, has been extensively studied for its potential health benefits, including its effects on cognitive function, memory, and brain health. This synthesis aims to consolidate findings from multiple research papers to provide a comprehensive overview of the impact of resveratrol on memory, cognitive performance, and mental health.

Key Insights

Cognitive and Memory Performance in Aging and Disease Models:
- Resveratrol has been shown to improve learning and memory in aging models and diabetic rats by reducing oxidative stress, inflammation, and acetylcholinesterase activity, and by enhancing synaptic plasticity and neurogenesis .
- In healthy older adults, resveratrol supplementation improved memory performance, particularly in word retention, and increased hippocampal functional connectivity and glucose metabolism.
Mood and Cognitive Performance in Humans:
- A meta-analysis indicated that resveratrol does not significantly impact memory and cognitive performance in humans but may enhance mood by reducing fatigue and increasing vigor.
- Resveratrol administration in healthy adults increased cerebral blood flow during cognitive tasks, although it did not significantly affect cognitive function.
Mechanisms of Action:
- The beneficial effects of resveratrol on cognitive function are linked to its antioxidant and anti-inflammatory properties, modulation of nitric oxide synthesis, and promotion of vasodilation, which improve blood flow and reduce oxidative damage .
- Resveratrol's neuroprotective effects are also associated with the upregulation of brain-derived neurotrophic factor (BDNF) through the microRNA-CREB pathway, enhancing neuroplasticity and memory formation .

Conclusion

Resveratrol demonstrates potential benefits for cognitive function and memory, particularly in aging and disease models, by reducing oxidative stress, inflammation, and enhancing neuroplasticity. While its effects on cognitive performance in healthy humans are less clear, resveratrol may improve mood and cerebral blood flow. These findings suggest that resveratrol could be a valuable supplement for maintaining brain health and mitigating age-related cognitive decline. Further research, particularly randomized controlled trials in humans, is needed to confirm these benefits and elucidate the underlying mechanisms.

Resveratrol memory, cognitive, mental, brain

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Effect of resveratrol on cognitive and memory performance and mood: A meta‐analysis of 225 patients

Resveratrol has no significant effect on memory and cognitive performance, but may enhance mood.

Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice.

Resveratrol, a polyphenolic phytoalexin, can reduce oxidative damage and improve cognitive impairment in senescence-accelerated mice, offering a potential novel therapeutic strategy for age-related conditions.

Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats.

Resveratrol treatment prevents memory impairment and increases acetylcholinesterase activity in diabetic rats, improving cognition.

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

Supplementing with resveratrol improves memory performance, glucose metabolism, and hippocampal functional connectivity in older adults, offering potential for brain health strategies during aging.

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.

Orally administered resveratrol can modulate cerebral blood flow variables without affecting cognitive function in healthy adults.

Protective effects of resveratrol on aging-induced cognitive impairment in rats

Resveratrol improves cognitive function in aged rats by reducing age-related learning and memory impairment and inhibiting inflammatory cytokines.

Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway.

Resveratrol improves long-term memory formation and learning in aged mice through the microRNA-CREB-BDNF pathway, offering potential therapeutic targets against CNS disorders in aging.

Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity

Resveratrol supplementation improves cognitive performance and neuronal injury in diabetic rats by reducing oxidative stress and inflammation and inhibiting synapse loss.

Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age

Resveratrol treatment in Balb/C mice improves memory performance and neuroplasticity, suggesting potential benefits for successful cognitive aging.

Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation

Resveratrol treatment in late middle age improves memory and mood function in old age, with increased neurogenesis, microvasculature, and reduced glial activation in the hippocampus.

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