Safranal and LRP-1

Introduction

Safranal, a key component of saffron (Crocus sativus L.), has been studied for its potential therapeutic effects, particularly in the context of inflammation, diabetes, and pain management. This synthesis explores the current research on safranal's mechanisms of action and its potential applications, with a focus on its interaction with the NLRP3 inflammasome and other relevant pathways.

Key Insights

Anti-inflammatory Effects via NLRP3 Inflammasome Inhibition:
- Safranal inhibits the NLRP3 inflammasome by preventing ASC oligomerization, reducing IL-1β production, and suppressing NLRP3 expression and ATPase activity. This effect is mediated through the enhancement of NRF2 expression.
Antidiabetic Properties through PTP1B Inhibition:
- Safranal acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor, enhancing insulin signaling and glucose uptake in muscle cells. It improves glucose tolerance in diabetic mice, suggesting its potential as an antidiabetic agent.
Analgesic and Anti-inflammatory Effects via TRPA1 Channel:
- Safranal targets the TRPA1 channel in nociceptors, mediating pain signals and exerting antinociceptive effects. It stimulates TRPA1, leading to calcium responses and currents in neurons, and desensitizes the channel to further stimulation, which may contribute to its analgesic properties.

Conclusion

Safranal exhibits significant potential as a therapeutic agent due to its diverse biological activities. It inhibits the NLRP3 inflammasome, offering anti-inflammatory benefits, and acts as a PTP1B inhibitor, improving insulin sensitivity and glucose tolerance. Additionally, safranal's interaction with the TRPA1 channel suggests its utility in pain management. These multifaceted effects position safranal as a promising candidate for further research and development in treating chronic inflammation, diabetes, and pain.

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Safranal and LRP-1

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization.

Safranal, a component of saffron, shows potential as a preclinical drug candidate against NLRP3 inflammasome-triggered chronic inflammation by suppressing IL-1 release and preventing ASC oligomerization.

Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice.

Safranal, a PTP1B inhibitor found in saffron, activates insulin signaling and improves glucose tolerance in type 2 diabetic mice, suggesting its potential as an antidiabetic treatment.

TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal

Safranal, a constituent in Crocus sativus L., exerts analgesic properties by partially agonizing and selective desensitization of the TRPA1 channel, which mediates pain signals in nociceptors.

Purification and Characterization of Sa-Lrp, a DNA-Binding Protein from the Extreme Thermoacidophilic ArchaeonSulfolobus acidocaldarius Homologous to the Bacterial Global Transcriptional Regulator Lrp

Sa-Lrp, an archaeal homologue of the bacterial global transcriptional regulator Lrp, shows potential as a global transcriptional regulator and genome organizer in extreme thermoacidophilic archaea.

Spectroscopic and Molecular Docking Investigation on the Noncovalent Interaction of Lysozyme with Saffron Constituent “Safranal”

Safranal, a constituent of saffron, forms a complex with lysozyme, driven by hydrophobic forces and hydrogen bonding, with minimal impact on the secondary structure of lysozyme.

Affinity-based target deconvolution of safranal

Safranal, a component of Crocus sativus L., physically binds to beta actin, cytochrome b-c1 complex sub-unit 1, trifunctional enzyme sub-unit beta, and ATP synthase sub-unit alpha and beta, potentially explaining its pharmac

Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization.

LRP-1 expression in retinas of oxygen-induced neovascularized rats suggests it may play a role in modulating retinal neovascularization by regulating proteolytic activity.

LRP-1 Promotes Cancer Cell Invasion by Supporting ERK and Inhibiting JNK Signaling Pathways

LRP-1 promotes cancer cell invasion by activating ERK and inhibiting JNK signaling pathways, affecting focal adhesion disassembly and promoting cancer cell invasion.

Binding of safranal to whey proteins in aqueous solution: Combination of headspace solid-phase microextraction/gas chromatography with multi spectroscopic techniques and docking studies.

Safranal binding to whey proteins is primarily mediated by hydrophobic interactions and hydrogen bonds, with bovine serum albumin showing the highest affinity.

Experimental and computational investigation on the molecular interactions of safranal with bovine serum albumin: Binding and anti-amyloidogenic efficacy of ligand

Safranal binds to bovine serum albumin (BSA) and inhibits amyloid formation, stabilizing the protein's secondary structure and reducing surface hydrophobicity.

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